CpG island chromatin: a platform for gene regulation.

Journal article

The majority of mammalian gene promoters are encompassed within regions of the genome called CpG islands that have an elevated level of non-methylated CpG dinucleotides. Despite over 20 years of study, the precise mechanisms by which CpG islands contribute to regulatory element function remain poorly understood. Recently it has been demonstrated that specific histone modifying enzymes are recruited directly to CpG islands through recognition of non-methylated CpG dinucleotide sequence. These ...

Expand abstract

Authors: Blackledge, N; Klose, R

• Publication status: Published
• Journal: Epigenetics : official journal of the DNA Methylation Society
• Volume: 6
• Issue: 2
• Pages: 147-152
• Publication date: 2011-02-01
• DOI: 10.4161/epi.6.2.13640
• EISSN: 1559-2308
• ISSN: 1559-2294
• Language: English
• Keywords: Base Sequence; Histone Demethylases; DNA Methylation; Humans; F-Box Proteins; Promoter Regions, Genetic; DNA-Binding Proteins; Plants; Gene Silencing; Histones; Oxidoreductases, N-Demethylating; Epigenesis, Genetic; Gene Expression Regulation; Genome; Chromatin; CpG Islands; Animals; Regulatory Elements, Transcriptional