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Conjugal multiple sclerosis: population-based prevalence and recurrence risks in offspring. Canadian Collaborative Study Group.

Abstract:

From a population-based sample of 15,504 patients attending Canadian multiple sclerosis (MS) clinics, we have determined the frequency of conjugal MS and have estimated the recurrence risk in offspring of such matings. Twenty-three MS cases were found among 13,550 spouses of study probands for a crude conjugal rate of 0.17% (95% CI of 0.10%-0.24%). Despite ascertainment bias that expectedly inflates this number, this is a frequency intermediate between the point prevalence (0.1%) and lifetime...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, WTC Human Genetics
Role:
Author
Journal:
Annals of neurology
Volume:
48
Issue:
6
Pages:
927-931
Publication date:
2000-12-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:a92f3106-fca3-4ab8-8c63-ffcc44de4b5e
Source identifiers:
31793
Local pid:
pubs:31793

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