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A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes.

Abstract:

beta-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation of PKA (protein kinase A). Given the large diversity of PKA targets within cardiac cells, a precisely regulated and confined activity of such signalling pathways is essential for the specificity of response. PDEs (phosphodiesterases) constitute the only cAMP-degrading mechanism and are expressed in the cardiomyocyte in at least 5 famil...

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Publisher copy:
10.1042/bst0340510

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Biochemical Society transactions More from this journal
Volume:
34
Issue:
Pt 4
Pages:
510-511
Publication date:
2006-08-01
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Language:
English
Keywords:
Pubs id:
pubs:237654
UUID:
uuid:a927bff0-582c-4fa4-b135-475d024f6c45
Local pid:
pubs:237654
Source identifiers:
237654
Deposit date:
2013-11-16

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