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T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation.

Abstract:

T cell activation by nonself peptide-major histocompatibility complex (MHC) antigenic complexes can be blocked by particular sequence variants in a process termed T cell receptor antagonism. The inhibition mechanism is not understood, although such variants are encountered in viral infections and may aid immune evasion. Here, we study the effect of antagonist peptides on immunological synapse formation by T cells. This cellular communication process features early integrin engagement and T ce...

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Publisher copy:
10.1083/jcb.200404059

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
The Journal of cell biology
Volume:
166
Issue:
4
Pages:
579-590
Publication date:
2004-08-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:a92205a1-3772-4180-9928-2b9d4146d77b
Source identifiers:
482630
Local pid:
pubs:482630

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