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Journal article

CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas.

Abstract:

Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variant antigen on the surface of malaria-infected red blood cells. Antibody responses to PfEMP-1 correlate with immunity, and, therefore, PfEMP-1 may be a good candidate for a malaria vaccine. However, the specificity of CD4 T cells required for a protective variant-specific antibody response is not known. We have measured the CD4 T cell response to 3 different regions that are relatively homologous among different PfEMP-1 v...

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Publication status:
Published

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Publisher copy:
10.1086/339521

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Journal:
The Journal of infectious diseases
Volume:
185
Issue:
6
Pages:
812-819
Publication date:
2002-03-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:a91e381a-61cf-4f4c-b5a3-3dde14a511b4
Source identifiers:
38188
Local pid:
pubs:38188

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