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Randomized phase I trial HIV-CORE 003: Depletion of serum amyloid P component and immunogenicity of DNA vaccination against HIV-1

Abstract:
Background The failure of DNA vaccination in humans, in contrast to its efficacy in some species, is unexplained. Observational and interventional experimental evidence suggests that DNA immunogenicity may be prevented by binding of human serum amyloid P component (SAP). SAP is the single normal DNA binding protein in human plasma. The drug (R)-1-[6-[(R)-2-carboxypyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC, miridesap), developed for treatment of syste... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0197299

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
Expand authors...
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Grant:
MRC/DFIDConcordatagreements(MR-J008605/1,G1001757
MR/N023668/1
More from this funder
Grant:
MRC/DFIDConcordatagreements(MR-J008605/1,G1001757
MR/N023668/1
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
13
Issue:
5
Article number:
e0197299
Publication date:
2018-05-17
Acceptance date:
2018-04-27
DOI:
ISSN:
1932-6203
Pmid:
29772028
Source identifiers:
848141
Language:
English
Pubs id:
pubs:853654
UUID:
uuid:a9191ca7-327a-4886-802d-67a0f9073e91
Local pid:
pubs:853654
Deposit date:
2018-05-20

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