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Randomized phase I trial HIV-CORE 003: Depletion of serum amyloid P component and immunogenicity of DNA vaccination against HIV-1

Abstract:
Background The failure of DNA vaccination in humans, in contrast to its efficacy in some species, is unexplained. Observational and interventional experimental evidence suggests that DNA immunogenicity may be prevented by binding of human serum amyloid P component (SAP). SAP is the single normal DNA binding protein in human plasma. The drug (R)-1-[6-[(R)-2-carboxypyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC, miridesap), developed for treatment of syste... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0197299

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More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
Expand authors...
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Grant:
MRC/DFID Concordat agreements (MR-J008605/1, G1001757 and MR/N023668/1
More from this funder
Grant:
MRC/DFID Concordat agreements (MR-J008605/1, G1001757 and MR/N023668/1
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
13
Issue:
5
Pages:
Article: e0197299
Publication date:
2018-05-17
Acceptance date:
2018-04-27
DOI:
ISSN:
1932-6203
Pubs id:
pubs:853654
URN:
uri:a9191ca7-327a-4886-802d-67a0f9073e91
UUID:
uuid:a9191ca7-327a-4886-802d-67a0f9073e91
Local pid:
pubs:853654
Language:
English

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