- Abstract:
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Background The failure of DNA vaccination in humans, in contrast to its efficacy in some species, is unexplained. Observational and interventional experimental evidence suggests that DNA immunogenicity may be prevented by binding of human serum amyloid P component (SAP). SAP is the single normal DNA binding protein in human plasma. The drug (R)-1-[6-[(R)-2-carboxypyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC, miridesap), developed for treatment of syste... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.2MB)
-
- Publisher copy:
- 10.1371/journal.pone.0197299
-
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- Grant:
- MRC/DFID Concordat agreements (MR-J008605/1, G1001757 and MR/N023668/1
- Grant:
- MRC/DFID Concordat agreements (MR-J008605/1, G1001757 and MR/N023668/1
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 13
- Issue:
- 5
- Pages:
- Article: e0197299
- Publication date:
- 2018-05-17
- Acceptance date:
- 2018-04-27
- DOI:
- ISSN:
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1932-6203
- Pubs id:
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pubs:853654
- URN:
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uri:a9191ca7-327a-4886-802d-67a0f9073e91
- UUID:
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uuid:a9191ca7-327a-4886-802d-67a0f9073e91
- Local pid:
- pubs:853654
- Language:
- English
- Copyright holder:
- Borthwick et al.
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Borthwick et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Randomized phase I trial HIV-CORE 003: Depletion of serum amyloid P component and immunogenicity of DNA vaccination against HIV-1
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