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A gradient of silent substitution rate in the human pseudoautosomal region.

Abstract:

It has been demonstrated that recombination in the human p-arm pseudoautosomal region (p-PAR) is at least twenty times more frequent than the genomic average of approximately 1 cM/Mb, which may affect substitution patterns and rates in this region. Here I report the analysis of substitution patterns and rates in 10 human, chimpanzee, gorilla, and orangutan genes across the p-PAR. Between species silent divergence in the p-PAR forms a gradient, increasing toward the telomere. The correlation o...

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Publication status:
Published

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Publisher copy:
10.1093/molbev/msh032

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Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
Journal:
Molecular biology and evolution
Volume:
21
Issue:
2
Pages:
410-417
Publication date:
2004-02-05
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
URN:
uuid:a91666f3-da3b-4668-bdb2-6e6f8203bf06
Source identifiers:
49202
Local pid:
pubs:49202

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