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Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Abstract:

Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with other glucose-related traits). In this study, we tested the hypotheses that, in a very large scale GWAS, we ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.1002383

Authors


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National Institute for Health Research More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
14
Issue:
9
Pages:
e1002383
Publication date:
2017-09-01
Acceptance date:
2017-08-03
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pmid:
28898252
Source identifiers:
729263
Language:
English
Keywords:
Pubs id:
pubs:729263
UUID:
uuid:a90d76cc-09b3-414d-a8e4-37922700a684
Local pid:
pubs:729263
Deposit date:
2017-09-26

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