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Journal article

Application of a novel score test for genetic association incorporating gene-gene interaction suggests functionality for prostate cancer susceptibility regions.

Abstract:

AIMS: We introduce an innovative multilocus test for disease association. It is an extension of an existing score test that gains power over alternative methods by incorporating a parsimonious one-degree-of-freedom model for interaction. We use our method in applications designed to detect interactions that generate hypotheses about the functionality of prostate cancer (PRCA) susceptibility regions. METHODS: Our proposed score test is designed to gain additional power through the use of a ret...

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Publication status:
Published

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Publisher copy:
10.1159/000331222

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Journal:
Human heredity
Volume:
72
Issue:
3
Pages:
182-193
Publication date:
2011-01-01
DOI:
EISSN:
1423-0062
ISSN:
0001-5652
URN:
uuid:a90b9d66-63c7-485e-8a60-1ede752ce170
Source identifiers:
216318
Local pid:
pubs:216318

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