- Abstract:
-
AIMS: We introduce an innovative multilocus test for disease association. It is an extension of an existing score test that gains power over alternative methods by incorporating a parsimonious one-degree-of-freedom model for interaction. We use our method in applications designed to detect interactions that generate hypotheses about the functionality of prostate cancer (PRCA) susceptibility regions. METHODS: Our proposed score test is designed to gain additional power through the use of a ret...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1159/000331222
-
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- Journal:
- Human heredity
- Volume:
- 72
- Issue:
- 3
- Pages:
- 182-193
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1423-0062
- ISSN:
-
0001-5652
- URN:
-
uuid:a90b9d66-63c7-485e-8a60-1ede752ce170
- Source identifiers:
-
216318
- Local pid:
- pubs:216318
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Application of a novel score test for genetic association incorporating gene-gene interaction suggests functionality for prostate cancer susceptibility regions.
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