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Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.

Abstract:

The orphan receptor small heterodimer partner (SHP, NR0B2) modulates the transcription activity of the MODY1 gene HNF4a. Mutations in SHP were found in 7% of Japanese obese young-onset type 2 diabetic patients and were associated with moderate obesity and increased birth weight. We investigated SHP in 1927 U.K. subjects, examining relationships with type 2 diabetes, obesity, and birth weight. Sequencing of the coding region of SHP in 122 obese, young-onset type 2 diabetic patients detected th...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.52.5.1276

Authors


Mitchell, SM More by this author
Weedon, MN More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Shields, B More by this author
Wilkins-Wall, B More by this author
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Journal:
Diabetes
Volume:
52
Issue:
5
Pages:
1276-1279
Publication date:
2003-05-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:a904813f-636e-4cd8-89b6-7ab14f6bcb3a
Source identifiers:
9965
Local pid:
pubs:9965

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