Control of pulsatile insulin secretion in man.

Journal article

Plasma insulin and glucose concentrations were examined in man in a basal state from central venous samples taken at 1-min intervals for up to 2.5 h. Normal subjects have insulin oscillations of mean period 14 min (significant autocorrelation, p less than 0.0001) with changes in concentration of 40% over 7 min. The pulsation frequency was stable through cholinergic, endorphin, alpha-adrenergic or beta-adrenergic blockade, or small perturbations with glucose or insulin. Stimulation of insulin ...

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Authors: Matthews, DR; Lang, D; Burnett, M; Turner, R

• Publication status: Published
• Journal: Diabetologia
• Volume: 24
• Issue: 4
• Pages: 231-237
• Publication date: 1983-04-01
• DOI: 10.1007/bf00282705
• EISSN: 1432-0428
• ISSN: 0012-186X
• Language: English
• Keywords: Atropine; Middle Aged; Adult; Propranolol; Diabetes Mellitus; Male; Glucose; Sodium Salicylate; Blood Glucose; Naloxone; Kinetics; Tolbutamide; Vagotomy; Insulin; Female; Humans; Phentolamine; Aged