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Spontaneous neurotransmitter release and Ca2+--how spontaneous is spontaneous neurotransmitter release?

Abstract:

Neurotransmitter release from neurons takes place at specialized structures called synapses. Action potential-evoked exocytosis requires Ca(2+) influx through voltage-gated Ca(2+) channels. Spontaneous vesicle fusion occurs both in the absence of action potentials and without any apparent stimulus and is hence thought to be Ca(2+)-independent. However, increasing evidence shows that this form of neurotransmitter discharge can be modulated by changes in intracellular Ca(2+) concentration, sugg...

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Publication status:
Published

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Publisher copy:
10.1016/j.ceca.2007.02.008

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Cell calcium
Volume:
43
Issue:
1
Pages:
9-15
Publication date:
2008-01-01
DOI:
EISSN:
1532-1991
ISSN:
0143-4160
Source identifiers:
114305
Language:
English
Keywords:
Pubs id:
pubs:114305
UUID:
uuid:a902f6f8-e55e-48a1-843b-5756bd812751
Local pid:
pubs:114305
Deposit date:
2012-12-19

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