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Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.

Abstract:: Members of the p53 tumor suppressor family are expressed as multiple isoforms. Isoforms having an N-terminal transactivation domain are transcriptionally active while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the high expression level of ΔNp63α inhibits the tumour suppressor function of TAp73β. This can in principle be due to blocking of the promotor or by direct interaction between both protei...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Gebel, J., Luh, L., Coutandin, D., Osterburg, C., Löhr, F., Schäfer, B., Frombach, A., Sumyk, M., Buchner, L., Krojer, T., Salah, E., Mathea, S., Güntert, P., Knapp, S., & Dötsch, V. (2016). Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization. Cell Death & Differentiation, 23, 1930–1940.

MLA Style

Gebel, J., et al. “Mechanism of TAp73 Inhibition by ΔNp63 and Structural Basis of p63/p73 Hetero-Tetramerization.” Cell Death & Differentiation, vol. 23, Nature Publishing Group, 2016, pp. 1930–40.

Chicago Style

Gebel, J, L Luh, D Coutandin, C Osterburg, F Löhr, B Schäfer, A Frombach, et al. 2016. “Mechanism of TAp73 Inhibition by ΔNp63 and Structural Basis of p63/p73 Hetero-Tetramerization.” Cell Death & Differentiation 23: 1930–40.
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Files:: Knapp et al, Mechanism...

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Publisher copy:: 10.1038/cdd.2016.83

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+ Gebel, J More by this author

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+ Luh, L More by this author

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+ Coutandin, D More by this author

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+ Osterburg, C More by this author

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+ Löhr, F More by this author

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+ Deutsche Forschungsgemeinschaft More from this funder

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Wellcome Trust More from this funder

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Bibliographic Details

Publisher:: Nature Publishing Group Publisher's website
Journal:: Cell Death & Differentiation Journal website
Volume:: 23
Pages:: 1930–1940
Publication date:: 2016-10-01
Acceptance date:: 2016-07-12
DOI:: 10.1038/cdd.2016.83
ISSN:: 1476-5403 and 1350-9047

Item Description

Language:: English
Keywords:: p73

transcriptional activity

p63

tetramarization

p53 family
Pubs id:: pubs:653224
UUID:: uuid:a9029a09-b6d1-429b-839e-973e7e177ac8
Local pid:: pubs:653224
Source identifiers:: 653224
Deposit date:: 2016-11-08

Terms of use

Copyright holder:: Macmillan Publishers Limited
Copyright date:: 2016
Notes:: © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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