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The impact of vaccination and prior exposure on stool shedding of Salmonella Typhi and Salmonella Paratyphi in 6 controlled human infection studies

Abstract:
Background: Shedding of Salmonella Typhi or Paratyphi in the stool or urine leads to contamination of food or water, which is a prerequisite for transmission of enteric fever. Currently, there are limited data on the effect of vaccination or prior exposure on stool shedding. Methods: Six Salmonella Typhi or Paratyphi human challenge studies were conducted between 2011 and 2017. Participants were either unvaccinated or vaccinated with 1 of 4 vaccines: Vi-poly... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cid/ciy670

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Oxford college:
All Souls College
Role:
Author
ORCID:
0000-0001-6324-6559
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
Expand authors...
More from this funder
Grant:
Strategic Translational Award (grant number 092661)
Emergent BioSolutions More from this funder
European Vaccine Initiative More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
68
Issue:
8
Pages:
1265–1273
Publication date:
2018-09-25
Acceptance date:
2018-08-07
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pubs id:
pubs:911983
URN:
uri:a9003101-d925-4277-a3a2-bcd0601e057f
UUID:
uuid:a9003101-d925-4277-a3a2-bcd0601e057f
Local pid:
pubs:911983

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