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Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC?

Abstract:

Binding of both proteinase 3 (PR3) and myeloperoxidase (MPO) to endothelial cells (EC) has been suggested to be involved in the vascular damage seen in patients with Wegener's granulomatosis or microscopic polyangiitis. In the present study we investigated in detail the interaction of MPO and PR3 with cultured human umbilical vein endothelial cells (HUVEC) and its matrix products. In addition, we investigated whether interaction of PR3 or MPO with HUVEC monolayers also resulted in antibody-de...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics, Obstetrics and Gynaecology
Role:
Author
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Journal:
Clinical and experimental immunology
Volume:
97
Issue:
1
Pages:
52-60
Publication date:
1994-07-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:a8f596c3-63ea-406f-aaf3-cc702fff5f9a
Source identifiers:
35772
Local pid:
pubs:35772

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