Interaction and dose equivalence of salbutamol and salmeterol in patients with asthma.
OBJECTIVE: To examine the pharmacological interaction of salmeterol and salbutamol and to derive an estimate of dose equivalence of salmeterol for airway and systemic effects in patients with asthma. DESIGN: Randomised double blind crossover study. SUBJECTS: 12 patients with mild asthma. INTERVENTION: Placebo or salmeterol 50, 100, 200 micrograms given on separate days followed two hours later by inhaled salbutamol in cumulative doses up to 3600 micrograms. MAIN OUTCOME MEASURES: Change in fo...Expand abstract
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