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Interaction and dose equivalence of salbutamol and salmeterol in patients with asthma.

Abstract:

OBJECTIVE: To examine the pharmacological interaction of salmeterol and salbutamol and to derive an estimate of dose equivalence of salmeterol for airway and systemic effects in patients with asthma. DESIGN: Randomised double blind crossover study. SUBJECTS: 12 patients with mild asthma. INTERVENTION: Placebo or salmeterol 50, 100, 200 micrograms given on separate days followed two hours later by inhaled salbutamol in cumulative doses up to 3600 micrograms. MAIN OUTCOME MEASURES: Change in fo...

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Publisher copy:
10.1136/bmj.306.6877.543

Authors


Pavord, ID More by this author
Wisniewski, AF More by this author
Williams, J More by this author
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Journal:
BMJ (Clinical research ed.)
Volume:
306
Issue:
6877
Pages:
543-545
Publication date:
1993-02-05
DOI:
EISSN:
1756-1833
ISSN:
0959-8138
URN:
uuid:a8f14e41-36bf-47ac-91be-af023edd110c
Source identifiers:
435416
Local pid:
pubs:435416

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