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The evolution of tumour composition during fractionated radiotherapy: implications for outcome

Abstract:

Current protocols for delivering radiotherapy are based primarily on tumour stage and nodal and metastases status, even though it is well known that tumours and their microenvironments are highly heterogeneous. It is well established that the local oxygen tension plays an important role in radiation-induced cell death, with hypoxic tumour regions responding poorly to irradiation. Therefore, to improve radiation response, it is important to understand more fully the spatiotemporal distribution...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s11538-018-0391-9

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Oxford college:
St Johns College
ORCID:
0000-0002-0146-9164
Enderling, H More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Publisher:
Springer US Publisher's website
Journal:
Bulletin of Mathematical Biology Journal website
Volume:
80
Issue:
5
Pages:
1207–1235
Publication date:
2018-02-27
Acceptance date:
2018-01-07
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
Pubs id:
pubs:817601
URN:
uri:a8f070f6-e1ca-41f6-8308-fa1c45be1441
UUID:
uuid:a8f070f6-e1ca-41f6-8308-fa1c45be1441
Local pid:
pubs:817601

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