- Abstract:
-
A series of natural epimers of alpha-homonojirimycin and its N-alkylated derivatives have been prepared to investigate the contribution of the different chiral centers and conformation of the specificity and potency of inhibition of glycosidases. These epimers and N-alkylated derivatives are alpha-homonojirimycin (1), beta-homonojirimycin (2), alpha-homomannojirimycin (3), beta-homomannojirimycin (4), alpha-3,4-di-epi-homonojirimycin (5), beta-4,5-di-epi-homonojirimycin (6), N-methyl-alpha-ho...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/jm970836l
-
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- Journal:
- Journal of medicinal chemistry
- Volume:
- 41
- Issue:
- 14
- Pages:
- 2565-2571
- Publication date:
- 1998-07-05
- DOI:
- EISSN:
-
1520-4804
- ISSN:
-
0022-2623
- URN:
-
uuid:a8ecd3ee-256e-4067-b7ff-2c9d94991c37
- Source identifiers:
-
36196
- Local pid:
- pubs:36196
- Language:
- English
- Keywords:
- Copyright date:
- 1998
Journal article
Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.
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