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Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.

Abstract:

A series of natural epimers of alpha-homonojirimycin and its N-alkylated derivatives have been prepared to investigate the contribution of the different chiral centers and conformation of the specificity and potency of inhibition of glycosidases. These epimers and N-alkylated derivatives are alpha-homonojirimycin (1), beta-homonojirimycin (2), alpha-homomannojirimycin (3), beta-homomannojirimycin (4), alpha-3,4-di-epi-homonojirimycin (5), beta-4,5-di-epi-homonojirimycin (6), N-methyl-alpha-ho...

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Publication status:
Published

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Publisher copy:
10.1021/jm970836l

Authors


Nishida, M More by this author
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Journal:
Journal of medicinal chemistry
Volume:
41
Issue:
14
Pages:
2565-2571
Publication date:
1998-07-05
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
URN:
uuid:a8ecd3ee-256e-4067-b7ff-2c9d94991c37
Source identifiers:
36196
Local pid:
pubs:36196

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