Journal article icon

Journal article

Infectious delivery of 120-kilobase genomic DNA by an epstein-barr virus amplicon vector.

Abstract:

It has been shown in a wide variety of contexts that persistent gene expression can best be obtained by using the genomic locus of a transgene. However, the size of most genomic loci precludes their use in current viral gene therapy vectors. Large transgene capacity and extrachromosomal persistence make Epstein-Barr virus (EBV) a promising vector to deliver genomic transgenes for gene therapy. We constructed an EBV amplicon vector that contains the EBV lytic origin of replication, the termina...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1006/mthe.2002.0557

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Molecular therapy : the journal of the American Society of Gene Therapy More from this journal
Volume:
5
Issue:
4
Pages:
427-435
Publication date:
2002-04-01
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Language:
English
Keywords:
Pubs id:
pubs:113601
UUID:
uuid:a8eacd01-154d-4fb9-8f67-071f78be8903
Local pid:
pubs:113601
Source identifiers:
113601
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP