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Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.

Abstract:

Somatostatin hyperpolarized rat pancreatic alpha-cells and inhibited spontaneous electrical activity by activating a low-conductance K+ channel (0.9 pS with physiological ionic gradients). This channel was insensitive to tolbutamide (a blocker of ATP-sensitive K+ channels) and apamin (an inhibitor of small-conductance Ca(2+)-activated K+ channels). Channel activation was prevented by pre-treating the cells with pertussis toxin, indicating the involvement of G-proteins. A direct interaction be...

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Publication status:
Published

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Publisher copy:
10.1007/s004240000474

Authors


Gromada, J More by this author
Gotfredsen, CF More by this author
Buschard, K More by this author
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Journal:
Pflugers Archiv : European journal of physiology
Volume:
442
Issue:
1
Pages:
19-26
Publication date:
2001-04-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:a8dc315b-9d6b-4147-9d4c-9b06aa6e009d
Source identifiers:
8281
Local pid:
pubs:8281

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