Journal article
Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
- Abstract:
-
Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria elimination and threatens to spread to other malaria endemic areas. Understanding mechanisms of piperaquine (PPQ) resistance is crucial for tracking its emergence and spread, and to develop effective strategies for overcoming it. Here we analyze a mechanism of PPQ resistance in Cambodian parasites. Isolates exhibit a bimodal dose-response curve when exposed to PPQ, with the area under the curve quantifying ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Bill and Melinda Gates Foundation
More from this funder
Funding agency for:
Woodrow, C
White, N
Wirth, D
Grant:
OPP1040463
OPP1040463
OPP1053604
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Article number:
- 1769
- Publication date:
- 2018-05-02
- Acceptance date:
- 2018-03-30
- DOI:
- ISSN:
-
2041-1723
- Pmid:
-
29720620
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:846036
- UUID:
-
uuid:a8db003b-20a1-4b9d-9bc4-d4ae592c0535
- Local pid:
- pubs:846036
- Source identifiers:
-
846036
- Deposit date:
- 2018-05-05
Terms of use
- Copyright holder:
- © Bopp, et al 2018
- Copyright date:
- 2018
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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