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Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

Abstract:

Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria elimination and threatens to spread to other malaria endemic areas. Understanding mechanisms of piperaquine (PPQ) resistance is crucial for tracking its emergence and spread, and to develop effective strategies for overcoming it. Here we analyze a mechanism of PPQ resistance in Cambodian parasites. Isolates exhibit a bimodal dose-response curve when exposed to PPQ, with the area under the curve quantifying ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-04104-z

Authors


More by this author
Role:
Author
ORCID:
0000-0002-9412-9766
More by this author
Role:
Author
ORCID:
0000-0001-6699-3568
More from this funder
Name:
Bill and Melinda Gates Foundation
Funding agency for:
Woodrow, C
White, N
Wirth, D
Grant:
OPP1040463
OPP1040463
OPP1053604
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
9
Article number:
1769
Publication date:
2018-05-02
Acceptance date:
2018-03-30
DOI:
ISSN:
2041-1723
Pmid:
29720620
Language:
English
Keywords:
Pubs id:
pubs:846036
UUID:
uuid:a8db003b-20a1-4b9d-9bc4-d4ae592c0535
Local pid:
pubs:846036
Source identifiers:
846036
Deposit date:
2018-05-05

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