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Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization.

Abstract:

Transition metals can catalyse the stereoselective synthesis of cyclic organic molecules in a highly atom-efficient process called cycloisomerization. Many diastereoselective (substrate stereocontrol), and enantioselective (catalyst stereocontrol) cycloisomerizations have been developed. However, asymmetric cycloisomerizations where a chiral catalyst specifies the stereochemical outcome of the cyclization of a single enantiomer substrate-regardless of its inherent preference-are unknown. Here...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms10109

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More from this funder
Name:
European Community
Grant:
330364
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
EP/K503113/1
More from this funder
Name:
Chemical Structure Association Trust
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
7
Pages:
10109
Publication date:
2016-01-01
DOI:
EISSN:
2041-1723
Language:
English
Pubs id:
pubs:587551
UUID:
uuid:a8d3f373-bddc-499e-bc2d-eba3bd362a7e
Local pid:
pubs:587551
Source identifiers:
587551
Deposit date:
2016-02-08

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