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High-resolution structures of bacterially expressed soluble human CD59

Abstract:

CD59 is a membrane-bound glycoprotein that protects host cells from lysis by inhibiting the terminal pathway of complement, preventing the formation and insertion of the membrane attack complex (MAC). Crystals of bacterially expressed and nonglycosylated recombinant soluble human CD59 have been obtained from three crystallization conditions, each of which gave rise to a distinct crystal form. Each crystal form led to a crystal structure at high resolution (1.15, 1.35 and 1.8 Å). In one of the...

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Publisher copy:
10.1107/S1744309107033477

Authors


Johnson, S More by this author
Roversi, P More by this author
Hughes, TR More by this author
Smith, RAG More by this author
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Journal:
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Volume:
63
Issue:
8
Pages:
648-652
Publication date:
2007-07-28
DOI:
EISSN:
1744-3091
ISSN:
1744-3091
URN:
uuid:a8d33075-6713-4bd8-b685-8791960cbb51
Source identifiers:
148432
Local pid:
pubs:148432
Language:
English
Keywords:

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