Thesis
N.M.R. structural studies and modelling of modular proteins
- Abstract:
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This thesis focuses on structural studies of the fibronectin type 1 module (F1) of tissue-type plasminogen activator (t-PA) and the N-terminal src homology 2 (SH2) module of the p85α subunit of phosphatidylinositol-3-OH kinase (PI3-kinase). t-PA plays a key role in the dissolution of blood clots. It is the only serine protease that binds to the fibrin network of a thrombus and localises its activity to the site of a clot. The t-PA F1 module is critical to t-PA fibrin binding. This module w...
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- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
-
uuid:a8c88faa-08ee-4374-a384-b7116c551ef1
- Local pid:
- polonsky:2:10
- Source identifiers:
-
603851307
- Deposit date:
- 2017-10-04
Terms of use
- Copyright holder:
- Downing, A; Downing, Anna Kristina
- Copyright date:
- 1993
- Notes:
- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
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