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Applications of stable isotope dimethyl labeling in quantitative proteomics.

Abstract:

Mass spectrometry has proven to be an indispensable tool for protein identification, characterization, and quantification. Among the possible methods in quantitative proteomics, stable isotope labeling by using reductive dimethylation has emerged as a cost-effective, simple, but powerful method able to compete at any level with the present alternatives. In this review, we briefly introduce experimental and software methods for proteome analysis using dimethyl labeling and provide a comprehens...

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Publication status:
Published

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Publisher copy:
10.1007/s00216-012-6070-z

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
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Journal:
Analytical and bioanalytical chemistry
Volume:
404
Issue:
4
Pages:
991-1009
Publication date:
2012-09-01
DOI:
EISSN:
1618-2650
ISSN:
1618-2642
Source identifiers:
384551
Language:
English
Keywords:
Pubs id:
pubs:384551
UUID:
uuid:a8bdad2a-3bff-44ad-97b4-902deb533dc5
Local pid:
pubs:384551
Deposit date:
2013-11-16

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