- Abstract:
-
In the mid-1990s, whole-cell (wP) pertussis vaccines were associated with local and systemic adverse events, which prompted their replacement with acellular (aP) vaccines in many high-income countries. In the past decade rates of pertussis disease have increased in children receiving only acellular pertussis vaccines. We compared the immune responses to acellular pertussis boosters in children who received their initial doses with either wP or aP vaccines using activation-induced marker (AIM)...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1172/jci121309
-
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- Grant:
- HHSN272200900044C
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of Clinical Investigation Journal website
- Publication date:
- 2018-06-19
- DOI:
- EISSN:
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1558-8238
- ISSN:
-
0021-9738
- Pubs id:
-
pubs:859828
- URN:
-
uri:a8bc4946-5283-457a-b47f-cc0b388c6a95
- UUID:
-
uuid:a8bc4946-5283-457a-b47f-cc0b388c6a95
- Local pid:
- pubs:859828
- Language:
- English
- Keywords:
- Copyright holder:
- American Society for Clinical Investigation
- Copyright date:
- 2018
Journal article
Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters
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