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Journal article

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters

Abstract:

In the mid-1990s, whole-cell (wP) pertussis vaccines were associated with local and systemic adverse events, which prompted their replacement with acellular (aP) vaccines in many high-income countries. In the past decade rates of pertussis disease have increased in children receiving only acellular pertussis vaccines. We compared the immune responses to acellular pertussis boosters in children who received their initial doses with either wP or aP vaccines using activation-induced marker (AIM)...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci121309

Authors


da Silva Antunes, R More by this author
Carpenter, C More by this author
Cortese, M More by this author
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Publication date:
2018-06-19
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pubs id:
pubs:859828
URN:
uri:a8bc4946-5283-457a-b47f-cc0b388c6a95
UUID:
uuid:a8bc4946-5283-457a-b47f-cc0b388c6a95
Local pid:
pubs:859828

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