Journal article
Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters
- Abstract:
-
In the mid-1990s, whole-cell (wP) pertussis vaccines were associated with local and systemic adverse events, which prompted their replacement with acellular (aP) vaccines in many high-income countries. In the past decade rates of pertussis disease have increased in children receiving only acellular pertussis vaccines. We compared the immune responses to acellular pertussis boosters in children who received their initial doses with either wP or aP vaccines using activation-induced marker (AIM)...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1172/jci121309
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Authors
Funding
+ National Institute of Allergy and Infectious
Diseases
More from this funder
Grant:
HHSN272200900044C
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of Clinical Investigation Journal website
- Publication date:
- 2018-06-19
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- Pubs id:
-
pubs:859828
- URN:
-
uri:a8bc4946-5283-457a-b47f-cc0b388c6a95
- UUID:
-
uuid:a8bc4946-5283-457a-b47f-cc0b388c6a95
- Local pid:
- pubs:859828
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- American Society for Clinical Investigation
- Copyright date:
- 2018
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