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Journal article

Contrasting effects of ischemia on the kinetics of membrane voltage and intracellular calcium transient underlie electrical alternans.

Abstract:

Repolarization alternans has been considered a strong marker of electrical instability. The objective of this study was to investigate the hypothesis that ischemia-induced contrasting effects on the kinetics of membrane voltage and intracellular calcium transient (Ca(i)T) can explain the vulnerability of the ischemic heart to repolarization alternans. Ischemia-induced changes in action potential (AP) and Ca(i)T resulting in alternans were investigated in perfused Langendorff guinea pig hearts...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00502.2004

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
288
Issue:
1
Pages:
H400-H407
Publication date:
2005-01-01
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
Source identifiers:
164614
Language:
English
Keywords:
Pubs id:
pubs:164614
UUID:
uuid:a8b4d18d-8f69-4382-b812-4e46b693e45f
Local pid:
pubs:164614
Deposit date:
2012-12-19

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