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Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.

Abstract:
Highly potent N-substituted delta-lactams have been rationally designed and synthesized by a concise route with a one-pot tandem reaction as key step. These iminosugars show weak inhibition of wild-type beta-glucocerebrosidase but 3- to 6-fold increases in mutant enzyme activity (N370S).
Publication status:
Published

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Publisher copy:
10.1021/jm801506m

Authors


Reinkensmeier, G More by this author
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Journal:
Journal of medicinal chemistry
Volume:
52
Issue:
10
Pages:
3146-3149
Publication date:
2009-05-05
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
URN:
uuid:a8a5d78d-776d-4055-9c63-28316233befe
Source identifiers:
101104
Local pid:
pubs:101104

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