- Abstract:
-
Histidine containing reducible polycations based on CH(6)K(3)H(6)C monomers (His6 RPCs), are highly effective DNA transfection agents combining pH buffering endosomal escape mechanisms with rapid unpackaging following reduction in the cytoplasm. We examined their ability to mediate siRNA uptake into cells focusing on hepatocyte delivery. Co-delivery of EGFP siRNA with pEGFP plasmid DNA reduced reporter gene expression by 85%. However while DNA transfection efficiency increased with polymer si...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jconrel.2008.05.014
-
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- Journal:
- Journal of controlled release : official journal of the Controlled Release Society
- Volume:
- 130
- Issue:
- 1
- Pages:
- 46-56
- Publication date:
- 2008-08-05
- DOI:
- EISSN:
-
1873-4995
- ISSN:
-
0168-3659
- URN:
-
uuid:a8a22aac-0ccc-48d3-9efb-b38bf08dd3d5
- Source identifiers:
-
178701
- Local pid:
- pubs:178701
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Delivery of siRNA mediated by histidine-containing reducible polycations.
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