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Journal article

Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?

Abstract:

In the mid-1980s, new molecular tools enabled the biology of cytokine expression and regulation to be studied. Our group uncovered a TNF-dependent cascade in active rheumatoid synovium, suggesting that TNF might be a therapeutic target; this concept was supported in an animal model of the disease. The proof of concept was a series of clinical trials, which have led to marked changes in the therapy of human rheumatoid arthritis and subsequently of other diseases. The work with TNF clearly demo...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1090051

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of Immunology More from this journal
Volume:
185
Issue:
2
Pages:
791-794
Publication date:
2010-07-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:223972
UUID:
uuid:a8a079be-71d1-40a8-986c-0006249d7247
Local pid:
pubs:223972
Source identifiers:
223972
Deposit date:
2012-12-19

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