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Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.

Abstract:

Pso2/Snm1 plays a key role in the repair of DNA interstrand cross-links in yeast. Human cells possess three orthologues of Pso2; SNM1A, SNM1B/Apollo and SNM1C/Artemis. Studies using mammalian cells disrupted or depleted for these genes have yielded equivocal evidence that any of these is a true functional homologues of the yeast gene. Here we show that ectopic expression of only one of the three human orthologues, hSNM1A, effectively suppresses the sensitivity of yeast pso2 (snm1) disruptants...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
DNA repair
Volume:
7
Issue:
2
Pages:
230-238
Publication date:
2008-02-05
DOI:
EISSN:
1568-7856
ISSN:
1568-7864
URN:
uuid:a89959e5-3444-4993-b757-9226e9634f48
Source identifiers:
20299
Local pid:
pubs:20299

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