- Abstract:
-
Pso2/Snm1 plays a key role in the repair of DNA interstrand cross-links in yeast. Human cells possess three orthologues of Pso2; SNM1A, SNM1B/Apollo and SNM1C/Artemis. Studies using mammalian cells disrupted or depleted for these genes have yielded equivocal evidence that any of these is a true functional homologues of the yeast gene. Here we show that ectopic expression of only one of the three human orthologues, hSNM1A, effectively suppresses the sensitivity of yeast pso2 (snm1) disruptants...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.dnarep.2007.09.013
-
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- Journal:
- DNA repair
- Volume:
- 7
- Issue:
- 2
- Pages:
- 230-238
- Publication date:
- 2008-02-05
- DOI:
- EISSN:
-
1568-7856
- ISSN:
-
1568-7864
- URN:
-
uuid:a89959e5-3444-4993-b757-9226e9634f48
- Source identifiers:
-
20299
- Local pid:
- pubs:20299
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.
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