Journal article
Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: abolition of psychostimulant-induced locomotor activity in rats.
- Abstract:
-
Selective large scale destruction of mesolimbic dopamine-containing terminals is produced by bilateral injection of 8 mug of 6-hydroxydopamine (6OHDA) into the nucleus accumbens septi (NAS) of rats pretreated with pargyline and desipramine (DMI). The DMI prevents the destruction of the noradrenergic innervation of the forebrain normally produced by the NAS 6OHDA lesion, without affecting the destruction of dopamine-containing neurons. The locomotor stimulation produced by the psychostimulants...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/0014-2999(76)90352-6
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Bibliographic Details
- Journal:
- European journal of pharmacology
- Volume:
- 40
- Issue:
- 1
- Pages:
- 45-56
- Publication date:
- 1976-11-01
- DOI:
- EISSN:
-
1879-0712
- ISSN:
-
0014-2999
- Source identifiers:
-
5886
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:5886
- UUID:
-
uuid:a89856bb-3805-4475-8c4c-fe31b9220d5f
- Local pid:
- pubs:5886
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1976
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