The importance of T cell interactions with macrophages in rheumatoid cytokine production.

Journal article

The analysis of suppression of cytokines in rheumatoid synovial tissue and fluid pioneered the studies of human cytokines in diseased tissue due to the relative ease of staining samples, even at the height of the inflammatory process. These studies led to the study of synovial cytokine regulation, and the identification of TNF as a therapeutic target, which has been amply validated in clinical trials and now routine therapy. The next key question was how is TNF disregulated in synovium. Are t...

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Authors: Brennan, F; Foey, A; Feldmann, M

• Publication status: Published
• Journal: Current topics in microbiology and immunology
• Volume: 305
• Pages: 177-194
• Publication date: 2006-01-01
• DOI: 10.1007/3-540-29714-6_9
• ISSN: 0070-217X
• Language: English
• Keywords: Lymphocyte Activation; Cytokines; Macrophages; T-Lymphocytes; Signal Transduction; Humans; Arthritis, Rheumatoid; Cell Communication; Monocytes; Animals; Cell Lineage