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Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.

Abstract:

BACKGROUND: The addition of an acetyl group to protein N-termini is a widespread co-translational modification. NatB is one of the main N-acetyltransferases that targets a subset of proteins possessing an N-terminal methionine, but so far only a handful of substrates have been reported. Using a yeast nat3Δ strain, deficient for the catalytic subunit of NatB, we employed a quantitative proteomics strategy to identify NatB substrates and to characterize downstream effects in nat3Δ. RESULTS: Co...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2164-11-685

Authors


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Netherlands Proteomics Centre More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC genomics Journal website
Volume:
11
Issue:
1
Pages:
Article no. 685
Publication date:
2010-01-01
DOI:
EISSN:
1471-2164
ISSN:
1471-2164
Source identifiers:
384576

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