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Journal article

The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis.

Abstract:

Eukaryotic cilia and flagella are highly conserved structures composed of a canonical 9+2 microtubule axoneme. Comparative genomics of flagellated and non-flagellated eukaryotes provides one way to identify new putative flagellar proteins. We identified the Parkin co-regulated gene, or PACRG, from such a screen. Male mice deficient in PACRG are sterile, but its function has been little explored. The flagellated protozoan parasite Trypanosoma brucei possesses two homologues of PACRG. We perfor...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.02659

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More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
118
Issue:
Pt 23
Pages:
5421-5430
Publication date:
2005-12-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:a8933e16-13db-4166-86aa-69629f65dd1d
Source identifiers:
26661
Local pid:
pubs:26661

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