- Abstract:
-
Eukaryotic cilia and flagella are highly conserved structures composed of a canonical 9+2 microtubule axoneme. Comparative genomics of flagellated and non-flagellated eukaryotes provides one way to identify new putative flagellar proteins. We identified the Parkin co-regulated gene, or PACRG, from such a screen. Male mice deficient in PACRG are sterile, but its function has been little explored. The flagellated protozoan parasite Trypanosoma brucei possesses two homologues of PACRG. We perfor...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1242/jcs.02659
-
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- Journal:
- Journal of cell science
- Volume:
- 118
- Issue:
- Pt 23
- Pages:
- 5421-5430
- Publication date:
- 2005-12-05
- DOI:
- EISSN:
-
1477-9137
- ISSN:
-
0021-9533
- URN:
-
uuid:a8933e16-13db-4166-86aa-69629f65dd1d
- Source identifiers:
-
26661
- Local pid:
- pubs:26661
- Copyright date:
- 2005
Journal article
The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis.
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