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Journal article

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.

Abstract:

The thymus constitutes the primary lymphoid organ responsible for the generation of naive T cells. Its stromal compartment is largely composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for thymocyte maturation and selection. With senescence, a steady decline in the thymic output of T cells has been observed. Numeric and qualitative changes in the stromal compartment of the thymus resulting in reduced thymopoietic capacit...

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Publication status:
Published

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Authors


Hauri-Hohl, MM More by this author
Keller, MP More by this author
Barthlott, T More by this author
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Journal:
Blood
Volume:
112
Issue:
3
Pages:
626-634
Publication date:
2008-08-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:a88e244b-378d-487a-82de-8fbfb4fc0316
Source identifiers:
309033
Local pid:
pubs:309033

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