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Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction.

Abstract:

We investigated the effects of leukotriene (LT) D4 and its novel potent and selective antagonist L-660,711 on isolated rat hearts with chronic myocardial infarction. The left coronary artery was ligated permanently or for 30 or 60 min and followed by reperfusion. Hearts were isolated and perfused in the Langendorff mode 4 days, 4 wk, or 8 wk after the operation. Dose-response curves for LTD4 (12-240 ng/min) on coronary flow were shifted to the left in rats with permanent coronary occlusion fo...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Journal:
American journal of physiology
Volume:
266
Issue:
5 Pt 2
Pages:
H2068-H2073
Publication date:
1994-05-01
ISSN:
0002-9513
Source identifiers:
441414
Language:
English
Keywords:
Pubs id:
pubs:441414
UUID:
uuid:a88cc78e-05c2-465d-9911-e3e960de3e24
Local pid:
pubs:441414
Deposit date:
2014-02-08

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