Journal article icon

Journal article

A complex barcode underlies the heterogeneous response of p53 to stress.

Abstract:

The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is the promoter selectivity of p53 target genes. p53 is at the hub of numerous signalling pathways that are triggered in response to particular stresses, all of which can leave their mark on p53 by w...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nrm2451

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Journal:
Nature reviews. Molecular cell biology More from this journal
Volume:
9
Issue:
9
Pages:
702-712
Publication date:
2008-09-01
DOI:
EISSN:
1471-0080
ISSN:
1471-0072
Language:
English
Keywords:
Pubs id:
pubs:34356
UUID:
uuid:a8879030-1821-4fe4-b49e-193ab79c1250
Local pid:
pubs:34356
Source identifiers:
34356
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP