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Glucose metabolism and oxygen availability govern reactivation from latency of the human retrovirus HTLV-1

Abstract:

The human retrovirus HTLV-1 causes a haematological malignancy or neuroinflammatory disease in ~10% of infected individuals. HTLV-1 primarily infects CD4+ T-lymphocytes and persists as a provirus integrated in their genome. HTLV-1 appears transcriptionally latent in freshly-isolated cells; however, the chronically active anti-HTLV-1 cytotoxic T-cell response observed in infected individuals indicates frequent proviral expression in vivo. The kinetics and regulation of HTLV-1 proviral expressi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.chembiol.2017.08.016

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Merton College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
WT100291MA
More from this funder
Name:
Medical Research Council
Grant:
MR/K019090/1
Publisher:
Cell Press
Journal:
Cell Chemical Biology More from this journal
Volume:
24
Issue:
11
Pages:
1377-1387.e3
Publication date:
2017-09-28
Acceptance date:
2017-07-28
DOI:
EISSN:
2451-9456
ISSN:
2451-9456
Keywords:
Pubs id:
pubs:710262
UUID:
uuid:a88745e3-7c1a-42b1-9272-f433cebbe332
Local pid:
pubs:710262
Source identifiers:
710262
Deposit date:
2017-08-03

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