Characterization of Drosophila fruitless-gal4 transgenes reveals expression in male-specific fruitless neurons and innervation of male reproductive structures.

Journal article

The fruitless (fru) gene acts in the central nervous system (CNS) of Drosophila melanogaster to establish male sexual behavior. Genetic dissection of the locus has shown that one of the fru gene's promoter, P1, controls the spatial and temporal expression of male-specific FruM proteins critical to determining stereotypical male sexual behavior. By using the Gal4-expression system, we show that a 16-kb fragment of the fru P1 promoter's 5' regulatory region drives the expression of Gal4 in a su...

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Authors: Billeter, J; Goodwin, S

• Publication status: Published
• Journal: Journal of comparative neurology
• Volume: 475
• Issue: 2
• Pages: 270-287
• Publication date: 2004-07-01
• DOI: 10.1002/cne.20177
• EISSN: 1096-9861
• ISSN: 0021-9967
• Language: English
• Keywords: Neuromuscular Junction; Animals; Serotonin; Female; Central Nervous System; Male; Drosophila Proteins; Larva; Peripheral Nervous System; Drosophila melanogaster; Neurons; Nerve Tissue Proteins; Sex Characteristics; beta-Galactosidase; Promoter Regions, Genetic; Transcription Factors; Transgenes; Genes, Reporter; Genetic Vectors; Gene Expression Regulation, Developmental; Sex Differentiation; Animals, Genetically Modified; Neurites; Genitalia, Male; Recombinant Fusion Proteins