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Journal article

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.

Abstract:

Mouse beta-cells cultured at 15 mmol/l glucose for 72 h had reduced ATP-sensitive K+ (K(ATP)) channel activity (-30%), increased voltage-gated Ca2+ currents, higher intracellular free Ca2+ concentration ([Ca2+]i; +160%), more exocytosis (monitored by capacitance measurements, +100%), and greater insulin content (+230%) than those cultured at 4.5 mmol/l glucose. However, they released 20% less insulin when challenged with 20 mmol/l glucose. Glucose-induced (20 mmol/l) insulin secretion was red...

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Publication status:
Published

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Publisher copy:
10.2337/db06-1150

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Journal:
Diabetes
Volume:
56
Issue:
7
Pages:
1888-1897
Publication date:
2007-07-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
7842
Language:
English
Keywords:
Pubs id:
pubs:7842
UUID:
uuid:a87f35d0-1e33-45c8-96a1-3cd04a70a40e
Local pid:
pubs:7842
Deposit date:
2012-12-19

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