Mathematical model of hyperbaric oxygen therapy applied to chronic diabetic wounds.

Journal article

The failure of certain wounds to heal (including diabetic foot ulcers) is a significant socioeconomic issue for countries worldwide. There is much debate about the best way to treat these wounds and one approach that is shrouded with controversy is hyperbaric oxygen therapy (HBOT), a technique that can reduce the risk of amputation in diabetic patients.In this paper, we develop a six species mathematical model of wound healing angiogenesis and use it to investigate the effectiveness of HBOT, ...

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Authors: Flegg, J; Byrne, H; McElwain, D

• Publication status: Published
• Journal: Bulletin of mathematical biology
• Volume: 72
• Issue: 7
• Pages: 1867-1891
• Publication date: 2010-10-01
• DOI: 10.1007/s11538-010-9514-7
• EISSN: 1522-9602
• ISSN: 0092-8240
• Language: English
• Keywords: Wound Healing; Computer Simulation; Humans; Hyperbaric Oxygenation; Models, Biological; Oxygen; Diabetic Foot