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A small amount of fat does not affect piperaquine exposure in patients with malaria.

Abstract:

Dihydroartemisinin-piperaquine is a new, highly effective, and well-tolerated combination treatment for uncomplicated falciparum malaria. The lipophilic characteristic of piperaquine suggests that administration together with fat will increase the oral bioavailability of the drug, and this has been reported for healthy volunteers. This pharmacokinetic study monitored 30 adult patients with uncomplicated falciparum malaria for 4.5 months to evaluate the effects of the concomitant intake of fat...

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Publisher copy:
10.1128/AAC.00279-11

Authors


Annerberg, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Khrutsawadchai, S More by this author
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Journal:
Antimicrob Agents Chemother
Volume:
55
Issue:
9
Pages:
3971-3976
Publication date:
2011-09-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:a87ac96c-3282-4450-ab75-d1493b9c144e
Source identifiers:
163939
Local pid:
pubs:163939

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