Dihydroartemisinin-piperaquine is a new, highly effective, and well-tolerated combination treatment for uncomplicated falciparum malaria. The lipophilic characteristic of piperaquine suggests that administration together with fat will increase the oral bioavailability of the drug, and this has been reported for healthy volunteers. This pharmacokinetic study monitored 30 adult patients with uncomplicated falciparum malaria for 4.5 months to evaluate the effects of the concomitant intake of fat...Expand abstract
- Publisher copy:
- Copyright date:
- PMCID: PMC3165307
A small amount of fat does not affect piperaquine exposure in patients with malaria.
If you are the owner of this record, you can report an update to it here: Report update to this record