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Molecular requirements of high-fidelity replication-competent DNA backbones for orthogonal chemical ligation.

Abstract:

The molecular properties of the phosphodiester backbone that made it the evolutionary choice for the enzymatic replication of genetic information are not well understood. To address this, and to develop new chemical ligation strategies for assembly of biocompatible modified DNA, we have synthesized oligonucleotides containing several structurally and electronically varied artificial linkages. This has yielded a new highly promising ligation method based on amide backbone formation that is che...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/jacs.6b11530

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
139
Issue:
4
Pages:
1575-1583
Publication date:
2017-01-01
Acceptance date:
2017-01-02
DOI:
ISSN:
1520-5126
Source identifiers:
671750
Language:
English
Keywords:
Pubs id:
pubs:671750
UUID:
uuid:a879d033-a28b-438b-a326-3e99a70ec904
Local pid:
pubs:671750
Deposit date:
2017-02-13

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