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Journal article

Leukocyte adhesion deficiency II: therapy and genetic defect.

Abstract:

Leukocyte adhesion deficiency II (LAD II) is a rare congenital disease which is caused by a defect in fucosylation of glycoconjugates. Hypofucosylated structures include ligands for the selectin family of adhesion molecules. This results in a leukocyte adhesion defect causing an immunodeficiency. In addition, LAD II patients show severe mental and growth retardations suggesting a role of fucose in development. Recently, a LAD II patient was treated with oral supplementation of fucose. This si...

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Publication status:
Published

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Publisher copy:
10.1159/000066968

Authors


Journal:
Cells, tissues, organs
Volume:
172
Issue:
3
Pages:
161-173
Publication date:
2002-01-01
DOI:
EISSN:
1422-6421
ISSN:
1422-6405
Source identifiers:
32269
Language:
English
Keywords:
Pubs id:
pubs:32269
UUID:
uuid:a86de964-a7fb-436c-8ac5-4a6b2074e6f8
Local pid:
pubs:32269
Deposit date:
2012-12-19

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