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The first example of molecularly imprinted nanogels with aldolase type I activity

Abstract:

The molecular-imprinting approach was used to obtain a nanogel preparation capable of catalysing the cross-aldol reaction between 4-nitrobenzaldehyde and acetone. A polymerisable proline derivative was used as the functional monomer to mimic the enamine-based mechanism of aldolase type I enzymes. The diketone template used to create the cavity was designed to imitate the intermediate of the aldol reaction and was bound to the functional monomer using a reversible covalent interaction prior to...

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Publisher copy:
10.1002/chem.200800675

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemistry - A European Journal
Volume:
14
Issue:
23
Pages:
7059-7065
Publication date:
2008-08-08
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Language:
English
Keywords:
Pubs id:
pubs:326205
UUID:
uuid:a866a55e-ff68-42af-9fe2-4cb0ec03bbbc
Local pid:
pubs:326205
Source identifiers:
326205
Deposit date:
2012-12-19

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