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Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations.

Abstract:

Osteoarthritis (OA) is the most common form of arthritis and a major cause of disability. This study evaluates the association in Caucasian populations of two single nucleotide polymorphisms (SNPs) mapping to the Human Leukocyte Antigen (HLA) region and deriving from a genome wide association scan (GWAS) of knee OA in Japanese populations. The frequencies for rs10947262 were compared in 36,408 controls and 5,749 knee OA cases from European-descent populations. rs7775228 was tested in 32,823 c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0023371

Authors


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Name:
Biotechnology and Biological Sciences Research Council
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Name:
Arthritis Research Campaign UK
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Name:
Estonian Ministry of Social Affairs
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Name:
Estonian Science Foundation
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Volume:
6
Issue:
8
Article number:
e23371
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203

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