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Tricalbins contribute to cellular lipid flux and form curved ER-PM contacts that are bridged by rod-shaped structures

Abstract:

Lipid flow between cellular organelles occurs via membrane contact sites. Extended-synaptotagmins, known as tricalbins in yeast, mediate lipid transfer between the endoplasmic reticulum (ER) and plasma membrane (PM). How these proteins regulate membrane architecture to transport lipids across the aqueous space between bilayers remains unknown. Using correlative microscopy, electron cryo-tomography, and high-throughput genetics, we address the interplay of architecture and function in budding ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-0168-0277
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Name:
Wellcome Trust
Grant:
202231/Z/16/Z
Publisher:
Elsevier
Journal:
Developmental Cell More from this journal
Volume:
51
Issue:
4
Pages:
488-502.e8
Publication date:
2019-11-18
Acceptance date:
2019-09-25
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
Pmid:
31743663
Language:
English
Keywords:
Pubs id:
pubs:1076128
UUID:
uuid:a8645aee-2af6-4e0d-b9d4-2033c93ed484
Local pid:
pubs:1076128
Source identifiers:
1076128
Deposit date:
2019-12-29

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