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Thesis

Inflammation and colorectal cancer: elucidation of the cellular and molecular mechanisms by which interleukin 22 contributes to the development and progression of colorectal cancer

Abstract:

Colorectal cancer (CRC) is a molecularly heterogeneous disease driven by the complex interplay between genetic factors, such as oncogenic mutations, and microenvironmental factors, such as aberrant immunity. Notably, interleukin 22 (IL- 22), which plays a critical role in intestinal epithelial repair, promotes CRC progression in murine models of both colitis-associated and sporadic CRC. However, the phenotypes associated with IL-22/IL-22 receptor expression in human CRC remain unchar...

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Department:
Nuffield Department of Medicine

Contributors

Department:
Kennedy Institute of Rheumatology, NDORMS
Role:
Supervisor
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Funding agency for:
Sarah McCuaig
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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