Thesis
Inflammation and colorectal cancer: elucidation of the cellular and molecular mechanisms by which interleukin 22 contributes to the development and progression of colorectal cancer
- Abstract:
-
Colorectal cancer (CRC) is a molecularly heterogeneous disease driven by the complex interplay between genetic factors, such as oncogenic mutations, and microenvironmental factors, such as aberrant immunity. Notably, interleukin 22 (IL- 22), which plays a critical role in intestinal epithelial repair, promotes CRC progression in murine models of both colitis-associated and sporadic CRC. However, the phenotypes associated with IL-22/IL-22 receptor expression in human CRC remain unchar...
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Authors
Contributors
+ Powrie, F
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
-
uuid:a8540c91-2b73-4065-8dbe-67202b9312d0
- Deposit date:
- 2018-02-13
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Terms of use
- Copyright holder:
- McCuaig, S
- Copyright date:
- 2017
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