Thesis icon

Thesis

Inflammation and colorectal cancer: elucidation of the cellular and molecular mechanisms by which interleukin 22 contributes to the development and progression of colorectal cancer

Abstract:

Colorectal cancer (CRC) is a molecularly heterogeneous disease driven by the complex interplay between genetic factors, such as oncogenic mutations, and microenvironmental factors, such as aberrant immunity. Notably, interleukin 22 (IL- 22), which plays a critical role in intestinal epithelial repair, promotes CRC progression in murine models of both colitis-associated and sporadic CRC. However, the phenotypes associated with IL-22/IL-22 receptor expression in human CRC remain unchar...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
More from this funder
Funding agency for:
McCuaig, S
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:a8540c91-2b73-4065-8dbe-67202b9312d0
Deposit date:
2018-02-13

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP