Inflammation and colorectal cancer: elucidation of the cellular and molecular mechanisms by which interleukin 22 contributes to the development and progression of colorectal cancer

Sarah McCuaig

Abstract:

Colorectal cancer (CRC) is a molecularly heterogeneous disease driven by the complex interplay between genetic factors, such as oncogenic mutations, and microenvironmental factors, such as aberrant immunity. Notably, interleukin 22 (IL- 22), which plays a critical role in intestinal epithelial repair, promotes CRC progression in murine models of both colitis-associated and sporadic CRC. However, the phenotypes associated with IL-22/IL-22 receptor expression in human CRC remain unchar...

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APA Style

McCuaig, S. (2017). Inflammation and colorectal cancer: elucidation of the cellular and molecular mechanisms by which interleukin 22 contributes to the development and progression of colorectal cancer [PhD thesis]. University of Oxford.

MLA Style

McCuaig, Sarah. Inflammation and Colorectal Cancer: Elucidation of the Cellular and Molecular Mechanisms by Which Interleukin 22 Contributes to the Development and Progression of Colorectal Cancer. University of Oxford, 2017.

Chicago Style

McCuaig, Sarah. 2017. “Inflammation and Colorectal Cancer: Elucidation of the Cellular and Molecular Mechanisms by Which Interleukin 22 Contributes to the Development and Progression of Colorectal Cancer.” PhD thesis, University of Oxford.
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