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Journal article

Contrasting within- and between-host immune selection shapes Neisseria Opa repertoires

Abstract:

Pathogen evolution is influenced strongly by the host immune response. Previous studies of the effects of herd immunity on the population structure of directly transmitted, short-lived pathogens have primarily focused on the impact of competition for hosts. In contrast, for long-lived infections like HIV, theoretical work has focused on the mechanisms promoting antigenic variation within the host. In reality, successful transmission requires that pathogens balance both within- and between-hos...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep06554

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific reports Journal website
Volume:
4
Pages:
6554
Publication date:
2014-10-09
Acceptance date:
2014-09-08
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Source identifiers:
486957
Language:
English
Keywords:
Pubs id:
pubs:486957
UUID:
uuid:a85319a0-8b5d-4468-be64-f31520fdd673
Local pid:
pubs:486957
Deposit date:
2016-05-02

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